RESUMO
In diabetic patients it has been shown that tolbutamide and carbutamide enhanced and glibenclamide did not influence the incidence of digitalis intoxication, or that of multifocal ectopic beats or coupling due to premature ectopic ventricular beats during digitalis therapy. In rabbits glibenclamide decreased and tolbutamide and carbutamide increased strophanthidin toxicity in a dose dependent manner. It was concluded that glibenclamide should be preferred to tolbutamide or carbutamide in digitalis-treated diabetics, when satisfactorily metabolic control is not achieved with a dietary regime alone.
Assuntos
Glicosídeos Cardíacos/toxicidade , Coração/efeitos dos fármacos , Hipoglicemiantes/toxicidade , Idoso , Animais , Carbutamida/toxicidade , Relação Dose-Resposta a Droga , Feminino , Glibureto/toxicidade , Humanos , Masculino , Pessoa de Meia-Idade , Coelhos , Tolbutamida/toxicidadeRESUMO
The oral treatment of eight diabetic patients with B.Z.55 (carbutamide) is reported. Two middle aged non-obese patients and one underweight patient responded satisfactorily and were discharged taking the drug. Two underweight Type II patients responded well to 8 and 10 g. per day. One "J" Type patient showed no response. Toxic effects were common with the high dosage employed. (AU)
